Scientific Publications
Shigamabs
TLN-4601
- 2010-07 A Phase II Trial of TLN-4601 in Patients with Glioblastoma Multiforme (GBM) at First Progression (PDF: 272 Kb)
- 2009-11 TLN-4601 is a Novel Tumor Selective Pro-Apoptotic Agent Acting Independently of Bax, Bak or Bcl-2 Expression (PDF: 683 Kb)
- 2009-04 TLN-4601, a Mutated K-Ras Signaling Inhibitor, offers a Therapeutic Option for TK Inhibitors in Resistant Cells with Activating K-Ras Mutations (PDF: 845 Kb)
- 2009-04 TLN-4601 specifically inhibits Ras-MAPK signaling upstream of MEK (PDF: 556 Kb)
- 2008-10 Biological and Biochemical Activity of TLN-4601 in Pancreatic Cancer (PDF: 292 Kb)
- 2008-07 Induction of Apoptosis in Immortalized T-Lymphocytes by TLN-4601 is Independent of Peripheral Benzodiazepine Receptor (PBR/TSPO) Binding (PDF: 1.21 Mb)
- 2008-04 Identification, characterization and potent antitumor activity of ECO-4601, a novel peripheral benzodiazepine receptor ligand.
- 2008-04 TLN-4601:A Potential New Therapeutic for the Treatment of Mutated K-Ras Mediated Cancers (PDF: 853 Kb)
- 2008-04 A structurally novel farnesylated dibenzodiazepinone, TLN-4601, inhibits wild-type, amplified and mutated EGFR glioma cell migration (PDF: 283 Kb)
- 2007-11 Targeted Delivery of ECO-4601 to Brain Tumors in an Orthotopic Model (PDF: 362 Kb)
- 2007-11 Safety and Efficacy of ECO-4601, a Novel Ras/MAPK Pathway Inhibitor and PBR Targeting Agent, in a Phase I Clinical Trial (PDF: 326 Kb)
- 2007-10 Phase I Pharmacokinetic Study of ECO-4601, a Novel Anticancer Bifunctional Targeting Agent (PDF: 242 Kb)
- 2007-04 ECO-4601, a novel anticancer drug and PBR ligand induces apoptosis through caspase-mediated events (PDF: 683 Kb)
- 2006-12 ECO-4601, A NOVEL ANTITUMOR COMPOUND TARGETING THE RAS-MAPK PATHWAY INDUCES APOPTOSIS (PDF: 2.09 Mb)
- 2006-11 The Anticancer Agent, ECO-4601, is a Potent Inhibitor of the Ras-Mitogen-Activated Protein Kinase Pathway (PDF: 655 Kb)
- 2006-11 Safety Profile in Primates of the Anticancer Agent ECO-4601, a Novel PBR Ligand and Ras Signalling Inhibitor (PDF: 240 Kb)
- 2006-08 ECO-4601, a Novel Peripheral Benzodiazepine Receptor Ligand, is also a Potent Inhibitor of the Ras-Mitogen-Activated Protein Kinase Pathway (PDF: 847 Kb)
- 2005-11 Antitumor Efficacy of ECO-4601 in Human Breast and Prostate Tumor Xenografts Correlates with Low and Sustained Drug Plasma Levels (PDF: 250 Kb)
- 2004-09 A NEW ANTITUMOR COMPOUND, ECO-4601: PRECLINICAL EVALUATION AND IN VIVO EFFICACY IN GLIOMA (PDF: 311 Kb)
- 2004-03 IDENTIFICATION AND CHARACTERIZATION OF A NEW CYTOTOXIC AGENT FROM ACTINOMYCETES (ECO-04601) (PDF: 243 Kb)
